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Delicious Cheesy Chicken Casserole

This Cheesy Chicken Casserole is comfort food at its finest—loaded with tender chicken, creamy sauce, and layers of melted cheese. It’s easy to make, loved by the whole family, and perfect for busy weeknights, meal prep, or sharing at potlucks. Cozy, creamy, and totally satisfying!

  • Total Time: 45–50 minutes
  • Yield: 6–8 servings 1x

Ingredients

Scale

For the Casserole:

  • 3 cups cooked, shredded chicken

  • 2 cups cooked pasta (elbow, penne, or rotini) or cooked rice

  • 1 can (10.5 oz) cream of chicken soup (or homemade)

  • 1/2 cup sour cream or plain Greek yogurt

  • 1 cup milk

  • 2 cups shredded cheddar cheese (or cheese blend)

  • 1/2 tsp garlic powder

  • 1/2 tsp onion powder

  • 1/2 tsp salt (adjust to taste)

  • 1/4 tsp black pepper

Optional Add-Ins:

  • 1 cup sautéed spinach or steamed broccoli

  • 1/2 cup chopped cooked bacon or ham

  • 1/2 tsp paprika or cayenne for heat

Topping:

  • 1 cup shredded cheese (cheddar, mozzarella, or mix)

  • 1/2 cup crushed crackers, breadcrumbs, or fried onions

  • 1 tbsp melted butter (optional for a golden crunch)

Instructions

  • Preheat your oven to 375°F (190°C) and lightly grease a 9×13” baking dish.

  • In a large mixing bowl, whisk together cream of chicken soup, sour cream, milk, garlic powder, onion powder, salt, and pepper.

  • Stir in the cooked chicken, pasta or rice, and 2 cups of shredded cheese. Add optional spinach or veggies if using.

  • Pour mixture into the prepared casserole dish and spread evenly.

  • Top with remaining 1 cup shredded cheese and crushed topping (mix with melted butter for extra crispness if desired).

  • Cover with foil and bake for 20 minutes.

  • Uncover and bake an additional 10–15 minutes, or until bubbly and golden.

 

  • Let rest for 5–10 minutes before serving.

Notes

  • Make it ahead: Assemble fully, cover tightly, and refrigerate up to 2 days before baking.

  • Freezer-friendly: Freeze unbaked or fully baked and cooled casserole. Thaw overnight in fridge before reheating.

  • Cheese matters: Freshly shredded cheese melts better than pre-shredded!

  • Add greens like spinach or kale for a nutrient boost without sacrificing comfort.

  • This recipe is great for rotisserie chicken or using up leftovers.

  • Author: Lily
  • Prep Time: 15 minutes
  • Cook Time: 30–35 minutes
  • Category: Dinner, Main Dish
  • Method: Baked
  • Cuisine: American Comfort Food

Keywords: Chicken And Spinach Casserole